What is difference between jQuery and Microsoft Ajax? When do you use Ajax and When do you use jQuery? What is the significance of each?

jQuery is like the ASP.NET AJAX Client Framework (MicrosoftAjax.js), with selectors, DOM selections/ manipulations, plug-ins, and better animation support.  jQuery is more powerful than MS AJAX on the client side due to its light weight nature .  This is the reason Microsoft integrated jQuery with Visual Studio. JQuery is integrated for post  VS versions 2008, no explicit download of jQuery file is required for the versions above VS2010.  

Ajax is a Technology for Asynchronous Data Transferring. AJAX is a technique to do an XMLHttpRequest  from a web page to the server and send or receive data to be used on the web page.

jQuery can be used

If you love and comfortable with JavaScript

Most interaction is client-side only

If a custom solution is required

For stunning look and feel of client side UI

If animations ,DOM Selection are required

Ajax can be used

If you are using ASP.NET & VS

When server side Integration is required.

If you need json and WCF Support

Read more: Beyond Realtional

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